RUNX2 monoclonal antibody (M01), clone 1D8
产品名称: RUNX2 monoclonal antibody (M01), clone 1D8
英文名称: RUNX2 monoclonal antibody (M01), clone 1D8
产品编号: H00000860-M01
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant RUNX2.
- Immunogen:
- RUNX2 (NP_004339, 251 a.a. ~ 350 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- NPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGA
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2b
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Runt-related transcription factor 2 (RUNX2) in human colon carcinoma: A potent prognostic factor associated with estrogen receptor.
Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, Takagi K, Onodera Y, Miki Y, Watanabe M, Ishida K, Ohnuma S, Sasaki H, Sato R, Karasawa H, Shibata C, Unno M, Sasaki I, Sasano H.Int J Cancer. 2012 Mar 7. doi: 10.1002/ijc.27525. [Epub ahead of print]
- Applications
- Western Blot (Cell lysate)
- RUNX2 monoclonal antibody (M01), clone 1D8. Western Blot analysis of RUNX2 expression in SJCRH30 ( Cat # L027V1 ).
- Protocol Download
- Western Blot (Cell lysate)
- RUNX2 monoclonal antibody (M01), clone 1D8 Western Blot analysis of RUNX2 expression in K-562 ( Cat # L009V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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- Immunoperoxidase of monoclonal antibody to RUNX2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
- Protocol Download
- Immunofluorescence
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- Immunofluorescence of monoclonal antibody to RUNX2 on U-2 OS cell . [antibody concentration 10 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged RUNX2 is approximately 0.03ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 860
- GeneBank Accession#:
- NM_004348
- Protein Accession#:
- NP_004339
- Gene Name:
- RUNX2
- Gene Alias:
- AML3,CBFA1,CCD,CCD1,MGC120022,MGC120023,OSF2,PEA2aA,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1
- Gene Description:
- runt-related transcription factor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq
- Other Designations:
- CBF-alpha 1,OTTHUMP00000016533,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit,acute myeloid leukemia 3 protein,core-binding factor, runt domain, alpha subunit 1,osteoblast-specific transcription factor 2,polyomavirus e
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Bone Diseases
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Cleidocranial Dysplasia
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Fractures, Bone
- Genetic Predisposition to Disease
- Metabolic Syndrome X
- Neoplasms
- Ossification of Posterior Longitudinal Ligament
- Osteoporosis
- Tobacco Use Disorder